정보 | The Total Synthesis of Natural Products
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작성자 Mildred 작성일25-08-04 02:53 조회6회 댓글0건본문
Cannabidiol-dimethylheptyl (CBD-DMH or DMH-CBD) is a synthetic homologue of cannabidiol where the pentyl chain has been replaced by a dimethylheptyl chain. Several isomers of this compound are known. The most commonly used isomer in research is (−)-CBD-DMH, which has the same stereochemistry as natural cannabidiol, and a 1,1-dimethylheptyl side chain. This compound is not psychoactive and acts primarily as an anandamide reuptake inhibitor, but is more potent than cannabidiol as an anticonvulsant and has around the same potency as an antiinflammatory. Another closely analogous compound has also been described, with the double bond in the cyclohexene ring shifted to between the 1,6-positions rather than the 2,3-positions (i.e. analogous to synthetic THC analogues such as parahexyl), the isopropenyl group saturated to isopropyl, and a 1,2-dimethylheptyl side chain. It is synthesized by Birch reduction from the 1,2-dimethylheptyl analogue of cannabidiol. This compound also produces potent cannabinoid-like effects in animals, but has three chiral centers and is composed of a mixture of eight stereoisomers, which have not been studied individually, so it is not known which stereoisomers are active.
Bisogno T, Hanus L, De Petrocellis L, Tchilibon S, Ponde DE, Brandi I, et al. October 2001). "Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide". British Journal of Pharmacology. 134 (4): 845-52. doi:10.1038/sj.bjp.0704327. Ben-Shabat S, Hanus LO, Katzavian G, Gallily R (February 2006). "New cannabidiol derivatives: synthesis, binding to cannabinoid receptor, and evaluation of their antiinflammatory activity". Journal of Medicinal Chemistry. 49 (3): 1113-7. doi:10.1021/jm050709m. Juknat A, Kozela E, Kaushansky N, Mechoulam R, Vogel Z (May 2016). "Anti-inflammatory effects of the cannabidiol derivative dimethylheptyl-cannabidiol - studies in BV-2 microglia and encephalitogenic T cells". Journal of Basic and Clinical Physiology and Pharmacology. 27 (3): 289-96. doi:10.1515/jbcpp-2015-0071. Hanus LO, Tchilibon S, Ponde DE, Breuer A, Fride E, Mechoulam R (March 2005). "Enantiomeric cannabidiol derivatives: synthesis and binding to cannabinoid receptors". Organic & Biomolecular Chemistry. 3 (6): 1116-23. doi:10.1039/B416943C. Fride E, Ponde D, Breuer A, Hanus L (June 2005). "Peripheral, but not central effects of cannalth Website|Try Ciao Health|Get Ciao Health CBD how to deal with them. When designing a bathroom, Ciao Health CBD|Ciao Health|CiaoHealthCBD.net|www.CiaoHealthCBD.net|Ciao Health CBD Gummies|Ciao CBD|CiaoHealth|CiaoHealthCBD|Ciao Health Review|Ciao Health CBD Review|Ciao CBD Gummies|Ciao Health CBD Oil|Ciao Health Supplement|Ciao Health Formula|Ciao Hemp Extract|Buy Ciao Health CBD|Order Ciao Health|Ciao Health Website|Try Ciao Health|Get Ciao Health CBD sit down and make a list of those things you must have, those things that would be nice to have, and those things you don't need. Check out more tips on how to design a bathroom on a budget. Because hiring labor to remodel a bathroom is probably the most costly part of renovation, www.CiaoHealthCBD.net it makes sense to learn how to negotiate for prices and explain your expectations. Read this article to get tips on hiring contractors. Before you begin remodeling a bathroom, it's best to sit down and plan out the entire design project from start to finish. Find out what steps you should take before you begin renovating your bathroom.
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