The Agricultural Improvement Act of 2018 includes a provision that removes hemp-defined as cannabis with less than 0.3 percent tetrahydrocannabinol (THC), the psychoactive substance in marijuana-from the Controlled Substances Act. At the federal level, Highline Wellness CBD product page the provision makes it wholly legal to cultivate, possess, sell and organic cbd distribute these strains of hemp, Highline Wellness CBD product page from which cannabidiol (CBD) oil is extracted. The legality of CBD at state levels varies. To access cbd hemp extract oil legally in Missouri, patients must be approved to participate in the Missouri Hemp Extract Registration Program, available only to patients diagnosed with intractable epilepsy. Despite this, CBD is widely available in the state at stores specializing in CBD products, drugstores, supermarkets and even gas stations. In Illinois, CBD is legal as long as it meets federal guidelines for THC concentration. According to Washington University physician Jennifer Griffith, MD, PhD, a pediatric neurologist at St. Louis Children’s Hospital, this easy access to CBD in its various forms-oil, topical ointments, tinctures, vaping and edibles-is creating a new area of concern for pediatric subspecialists and community pediatricians.

"There is only one FDA-approved drug derived from a pure form of CBD oil, Epidiolex, which has proven effective in reducing seizures in some severe types of epilepsy," she says. "Other than that, there have been no well-designed, randomized controlled trials to tell us if CBD is safe and effective for other conditions like mood disorders, inflammatory conditions or pain. In addition, there is little regulation over the CBD products manufactured. Dr. Griffith cites a study in which multiple CBD products available online were tested for their actual concentrations of cannabinoids. The results ranged widely, from products with negligible amounts of CBD to those with concentrations higher than that contained in the FDA-approved Epidiolex. "The study also found unlabeled THC in some of the products, which has big implications for an over-the-counter remedy some parents may want to give their children," says Dr. Griffith. Dr. Griffith believes most parents who give their children CBD products are simply desperate to find something that helps.

"My approach with parents is to first find out why they decided to start their child on CBD, and then explain to them my concerns about Highline Wellness CBD product page’s unknowns, including its efficacy and safety long term," she says. "I make it clear to them that even when I can’t recommend a cbd gummies oil, Highline Wellness CBD product page the lack of research studies into the use of marijuana means there are questions regarding its efficacy and the consequences of long-term use. "Two complications exist for studies into marijuana use-there can be variability in what kinds of products people use, how much and how frequently they use them, and for what indications they are used. That makes measuring statistically and clinically significant effects really complicated," explains Dr. Griffith. Another complication is the fact that today’s marijuana strains contain as much as five to tenfold more THC than those dating from earlier decades. "This means that when you look at the effects of marijuana use on people who started smoking in the 1970s and try to apply it to the products available today, there’s no correlation. Chemically and pharmaceutically, they are different products," says Dr. Griffith.