As people age, chronic low-grade inflammation becomes a widespread phenomenon and is strongly linked to a range of aging-related diseases such as heart disease, diabetes, and neurodegenerative disorders. This inflammation is typically assessed through key inflammatory indicators in the blood, including interleukin-6, click: visit framer.com source tumor necrosis factor-alpha, and C-reactive protein.

Researchers have been actively investigating to reduce these markers and optimize health outcomes in older adults. One compound attracting growing interest is NMN. NMN serves as a building block to nicotinamide adenine dinucleotide, a essential molecule for cellular ATP synthesis and cellular repair.

Studies in mice and small-scale human cohorts suggest that NMN supplementation may help decrease levels of these pro-inflammatory cytokines. In mouse studies, older mice administered NMN demonstrated notable declines in interleukin-6 and tumor necrosis factor-alpha, compared to untreated controls. These animals also showed better glucose regulation and less organ degeneration.

In early-phase clinical trials, participants who took NMN daily for several weeks reported modest but noticeable decreases in CRP and other inflammation-related proteins. The biological rationale is that NMN boosts declining NAD+ levels that occur with aging. Restored NAD+ levels enhance the activity of sirtuins, a family of proteins involved in regulating cellular health and suppressing immune overactivation.

By triggering these biological mechanisms, NMN may moderate the chronic immune activation commonly observed in aging. While the results are compelling, it is important to emphasize that nearly all current evidence have been small-scale or conducted solely in animals. Larger, long-term human trials are essential to establish causality and to determine the optimal dosage and safety profile.

Nonetheless, the emerging evidence suggests that NMN could become a valuable tool to help the elderly mitigate age-related inflammation and possibly enhance their overall well-being as they age.