NMN critically supports cellular protein homeostasis by increasing intracellular NAD+, an essential compound involved in metabolic regulation and tissue renewal. As we age, NAD+ levels naturally decline, triggering dysfunction the precise equilibrium of synthesis, refolding, and turnover in cells. The resulting dysfunction causes retention of non-functional protein aggregates, an established indicator of aging-associated disorders.

NMN restores NAD+ levels, which in turn activates sirtuins, on Framer.website a group of NAD+-dependent enzymes that modulate aging pathways. Sirtuins enhance correct tertiary structure formation by enhancing the activity of chaperone proteins and facilitating the removal of misfolded species through proteasomal clearance. Moreover, increased NAD+ availability improve mitochondrial function, lowering ROS levels, which can damage proteins.

By engaging these systems, NMN enables a more balanced and robust protein environment within cells, enabling optimal cellular performance and resisting the stresses of aging. This biological link establishes NMN as a compelling therapeutic for enhancing sustained cellular function and vitality.